Structural genomics: Computational methods for structure analysis
LBHIDDEN[0]LBHIDDEN[quote]REVIEWStructural genomics: Computational methods for structure analysis _*H _iF*iP:H%P
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Abstract
The success of structural genomics initiatives requires the development and application of tools for structure analysis, prediction, and annotation. In this paper we review recent developments in these areas; specifically
structure alignment, the detection of remote homologs and analogs, homology modeling and the use of structures to predict function. We also discuss various rationales for structural genomics initiatives. These include the structure-based clustering of sequence space and genome-wide function assignment. It is also argued that structural genomics can be integrated into more traditional biological research if specific biological questions are included in target selection strategies.Keywords: Structural genomics; homology modeling; structure alignments; functional analysis.[/quote]3qc E8k#Z
[quote]结构基因组：在结构分析中的计算方法 `G%u [)d#|y G e6W
随着结构基因组的发展，对结构进行分析，预测，注释的工具的应用和发展越来越重要了。在这篇review中作者从四个方面介绍了这个领域近来的发展：特异的结构比对（specifically structure alignment），进化距离远的同源及类似蛋白的检测（detection of remote homologs and analogs），同源建模（homology modeling）和从结构预测功能（use of structures to predict function）。作者还对结构基因组的各种理论进行了探讨，包括基于结构的序列空间聚类和基因组范围的功能识别等。gC)md4JAR
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