新加坡科学家提出一个紧凑微电极列阵(MEA)系统，对从PC12神经系统的细胞的研究钾离子导致的多巴胺发行，无需依靠微细器和显微镜。 MEA芯片集成了与一套定制的“测试夹具”，与potentiostat和一个microfluidic注射器泵浦一起提供在微集成电路和大环境之间的一个健壮电子连接的工具。 这个集成系统极大简化操作做法，提高感觉表现，并且减少制造费用。 多巴胺的达到的检测极限是3.8 × 10-2 M (信号或噪声、S/N = 3)和多巴胺线性定标范围是7.39 ± 0.06 M (卑鄙± SE)。 微电极的extracelluar矩阵胶原涂层的作用对感觉行为的多巴胺，以及K+和L-3,4-digydroxyphenylalanine集中的影响和在多巴胺发行的孵出时间，广泛地被学习了。 结果表示，该系统是非常合适的为了生物学家能学习从生存细胞的化工发行并且对藏匿细胞的药品效应。 也显示在进一步改善的潜力往药物掩护应用的一个multichip列阵系统。

This paper presents a compact microelectrode array (MEA) system, to study potassium ion-induced dopamine release from PC12 neural cells, without relying on a micromanipulator and a microscope. The MEA chip was integrated with a custom-made "test jig", which provides a robust electrical interfacing tool between the microchip and the macroenvironment, together with a potentiostat and a microfluidic syringe pump. This integrated system significantly simplifies the operation procedures, enhances sensing performance, and reduces fabrication costs. The achieved detection limit for dopamine is 3.8 × 10-2 M (signal/noise, S/N = 3) and the dopamine linear calibration range is up to 7.39 ± 0.06 M (mean ± SE). The effects of the extracelluar matrix collagen coating of the microelectrodes on dopamine sensing behaviors, as well as the influences of K+ and L-3,4-digydroxyphenylalanine concentrations and incubation times on dopamine release, were extensively studied. The results show that our system is well suited for biologists to study chemical release from living cells as well as drug effects on secreting cells. The current system also shows a potential for further improvements toward a multichip array system for drug screening applications.